The receptor for advanced glycation end products promotes bacterial growth at distant body sites in Staphylococcus aureus skin infection |
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| Institution: | 1. Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;2. Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;3. Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;1. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan;2. Department of Social Work, Tunghai University, Taichung, Taiwan;3. Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;4. Institute of Biomedical Sciences, National Chung Hsing University, Taichung 402, Taiwan;5. Rong Hsing Research Center for Translational Medicine, and National Chung Hsing University, Taichung 402, Taiwan;6. Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan;7. Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan;8. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;9. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan;10. Institute of Nuclear Energy Research, Atomic Energy Council, Longtan, Taoyuan, Taiwan;11. Department of Nutrition and Institute of Biomedical Nutrition and Hung-Kuang University, Taichung, Taiwan;12. Department of Food and Nutrition, Hung-Kuang University, Taichung, Taiwan;13. Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan;1. Department of Biomolecular Sciences, Section of Biochemistry and Molecular Biology, Università degli Studi “Carlo Bo”, via A. Saffi 2, 61029, Urbino, Italy;2. Istituto Auxologico Italiano, Neurobiology Laboratory, Strada Cadorna 90, 28824, Piancavallo di Oggebbio, Italy;3. Department of Life and Environmental Sciences, Università Politecnica delle Marche, via Brecce Bianche, 60131, Ancona, Italy;4. Institute of Ecosystem Study (ISE), Microbial Ecology Group (MEG), Consiglio Nazionale delle ricerche (CNR), largo V. Tonolli 50, 28922, Verbania, Italy;5. Section of Toxicological, Hygienistic and Environmental Sciences, Università degli Studi “Carlo Bo”, via A. Saffi 2, 61029, Urbino, Italy;1. Emergency Medicine Department, University of São Paulo, Brazil;2. Pathology Department, University of São Paulo, Brazil;3. Cell Biology Department, University of São Paulo, Brazil;4. PREMIUM Confocal Microscopy Core Facility, University of São Paulo, Brazil;5. Oncology Department, University of São Paulo, Brazil;1. Intensive Care Unit, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;2. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;3. Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA;4. Institute of Animal Quarantine, Chinese Academy of Inspection and Quarantine, Beijing, China;1. Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea;2. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea;3. KAIST Institute for the NanoCentury, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea |
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| Abstract: | The receptor for advanced glycation endproducts (RAGE) has been implicated in the regulation of skin inflammation. We here sought to study the role of RAGE in host defense during skin infection caused by Staphylococcus (S.) aureus, the most common pathogen in this condition. Wild-type (Wt) and RAGE deficient (rage?/?) mice were infected subcutaneously with S. aureus and bacterial loads and local inflammation were quantified at regular intervals up to 8 days after infection. While bacterial burdens were similar in both mouse strains at the primary site of infection, rage?/? mice had lower bacterial counts in lungs and liver. Skin cytokine and chemokine levels did not differ between groups. In accordance with the skin model, direct intravenous infection with S. aureus was associated with lower bacterial loads in lungs and liver of rage?/? mice. Together these data suggest that RAGE does not impact local host defense during S. aureus skin infection, but facilitates bacterial growth at distant body sites. |
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| Keywords: | Skin infection Innate immunity Receptor for advanced glycation endproducts |
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