Effect of ammonium ions on glycolipid production byCandida (Torulopsis)apicola |
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| Authors: | R K Hommel S Stegner H -P Kleber L Weber |
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| Institution: | (1) Cell Technologie Leipzig, Fontanestrasse 21, D-04289 Leipzig, Germany;(2) FB Biowissenschaften, Institut für Biochemie, Talstrasse 33, D-04103 Leipzig, Germany;(3) Hoffmann-La Roche AG, PRPV 15/128, CH-4032 Basel, Switzerland |
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| Abstract: | The effect of ammonium on growth ofCandida apicola and on production of sophorose lipid was studied. Sophorose lipid production increased with increasing initial ammonium sulphate concentration. Both growth and product formation were strongly reduced at 73.6mm ammonium. With 58.9mm ammonium a microcrystalline sophorose lipid was formed. The ratio of the two isomers of the sophorose lipid, harbouring either  - or -1 hydroxy fatty acid, was influenced by the initial concentration of ammonium. Both production kinetics, yields and profiles of the total cellular fatty acids express alterations with enlarged ammonium concentrations. These results suggest regulatory effects of ammonium onC. apicola and its sophorose lipid synthesis.Dedicated to Prof. Dr. Fritz Wagner on the occasion of his 65th birthday |
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