HtrA2/Omi, a sheep in wolf's clothing |
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| Authors: | Vaux David L Silke John |
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| Institution: | The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, 3050, Victoria, Australia |
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| Abstract: | Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria. |
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