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Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis |
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| Authors: | McDermott Lee A Higgins Brian Simcox Mary Luk Kin-Chun Nevins Tom Kolinsky Kenneth Smith Melissa Yang Hong Li Jia K Chen Yingsi Ke June Mallalieu Navita Egan Tom Kolis Stan Railkar Aruna Gerber Louise Liu Jin-Jun Konzelmann Fred Zhang Zhuming Flynn Tom Morales Omar Chen Yi |
| Affiliation: | Hoffmann-La Roche Inc., 340 Kingsland Str., Nutley, NJ 07110-1199, USA. lee.mcdermott@roche.com |
| Abstract: | RO4396686 is a small molecule KDR, FGFR, and PDGFR inhibitor with good pharmacokinetic properties in rodents. In a mouse corneal neovascularization assay, this compound inhibited VEGF-induced angiogenesis. Tested in a H460a xenograft tumor model this agent effected significant tumor growth inhibition at doses as low as 50mg/kg. |
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