Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents |
| |
| Authors: | Albrecht Uwe Gördes Dirk Schmidt Enrico Thurow Kerstin Lalk Michael Langer Peter |
| |
| Affiliation: | Institut für Chemie, Universit?t Rostock, Albert-Einstein-Str. 3a, 18051 Rostock, Germany. |
| |
| Abstract: | 2-Alkylidenethiazolidine-4,5-diones were prepared by novel one-pot cyclizations of arylacetonitriles with isothiocyanates and ethyl 2-chloro-2-oxoacetate. The products show antibiotic activity against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
