Neuro-and psychotropic activity of N-uronoylamino acids and N-uronoylpeptides |
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Authors: | M. Yu. Ravaeva I. I. Korenyuk V. O. Kur’yanov T. A. Chupakhina V. Ya. Chirva |
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Affiliation: | (1) Vernadsky Tauric National University, pr. Vernadskogo 4, Simferopol, 95007, Crimea, Ukraine |
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Abstract: | Peculiarities of the rat behavior were studied in a series of experimental stress models after a systemic administration of new N-uronoyl derivatives of amino acids. The psychotropic effect was shown to be determined by the nature of the amino acid fragment. N-(1,2:3,4-Di-O-isopropylidene-α-D-galactopyraneuronoyl)-glycylglycine exhibited an anxiolytic effect more pronounced than that of pyracetam, whereas N-(1,2:3,4-di-O-isopropilidene-α-D-galactopyranuronoyl)-glycylglutamic acid has antidepressant action stronger than that of amitriptyline. Mechanisms for the psychotropic effects of the examined derivatives are discussed. |
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Keywords: | N-uronoylamino acids glycylglycine glutamic acid neurotropic activity psychotropic activity |
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