Colchicine resistance in human cell lines. Pleiotropic phenotype and decreased membrane permeability |
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| Authors: | Y. Chamla J. Bégueret |
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| Affiliation: | (1) Laboratoire de Cytogénétique, Hôpital des Enfants, F-33077 Bordeaux-Cedex, France;(2) Laboratoire de Génétique, Avenue des Facultés, F-33405 Talence-Cedex, France |
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| Abstract: | Summary Colchicine-resistant human cells were initially observed in patients exhibiting C-anaphases or tetraploidy in lymphocyte cultures. Cell lines established from these patients displayed cross-resistances to daunomycin, emetine, vinblastine, and vincristine and collateral sensitivity to Xylocaine, showing a pleiotropic phenotype similar to that described in permeability mutants in CHO cells. 3H colchicine uptake and binding assays confirmed a decreased permeability to the drug. |
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