Different turnover of rat fetal and placental ornithine decarboxylases |
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| Authors: | J A López-Ballester J L Gómez-Skarmeta A Cremades R Pe?afiel |
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| Institution: | Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Murcia, Spain. |
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| Abstract: | The half-lives of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC) have been studied in fetuses and placentas from 18-day-pregnant rats. While the turnover of fetal and placental SAMDC were slightly different (t1/2 = 38 and 75 min, respectively) the half-lives of fetal and placental ODC differed markedly. T1/2 of fetal ODC was 15 min, similar to other mammalian ODCs, but placental ODC showed a relatively high half-life, about 160 min. According to that, placental ODC was more resistant than the fetal enzyme to in vivo hyperthermic treatment (40 degrees C, 1 h). Our results suggest that the degradative mechanisms for ODC in rat placenta could be regulated differently to those in other mammalian tissues. |
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