Antimutagenic effects of germanium oxide on Trp-P-2-induced frameshift mutations in Salmonella typhimurium TA98 and TA1538 |
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Authors: | T Kada H Mochizuki K Miyao |
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Institution: | Department of Anatomy, University of South Alabama, Mobile, AL 36688 U.S.A. |
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Abstract: | A germanium compound, germanium oxide (GeO2) behaved as a potent antimutagen on frameshift-type reverse mutations induced by 3-amino-1-methyl-5H-pyrido4,3-b]indole (Trp-P-2) in strains of Salmonella typhimurium TA98 and TA1538 with and without a plasmid pKM101, respectively. This metal antimutagen seems to work independently of the plasmid, a promotive factor in chemically induced mutagenesis through error-prone DNA repair. |
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Keywords: | Send correspondence to: K Lemone Yielding Department of Anatomy University of South Alabama Mobile AL 36688 U S A |
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