Arabidopsis AtNek2 Kinase is Essential and Associates with Microtubules |
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Authors: | Francesco Agueci Twan Rutten Dmitri Demidov Andreas Houben |
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Institution: | (1) Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Corrensstrasse 3, 06466 Gatersleben, Germany; |
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Abstract: | NIMA-related kinases (Neks) are a large family of serine/threonine kinases that have been linked to cell-cycle regulation
in fungi and mammals. Large families of NIMA-related kinases are also conserved in plants. We demonstrate that AtNek2, a member of the NIMA-related kinase family in Arabidopsis, is a gene fundamental for plant survival and its down-regulation has a pleiotropic effect on leaf cell morphogenesis and
plant development. Intracellular localization of YFP::AtNek2 showed that AtNek2 proteins co-distribute with the microtubular
cytoskeleton. As a microtubular-associated protein AtNek2 might influence the dynamics of microtubules and consequently cell
morphogenesis. This is supported by the observation that misexpression of AtNek2 in RNAi mutants leads to a distorted organization
of cells. |
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