Proteome analysis of the hyaluronic acid-producing bacterium, Streptococcus zooepidemicus |
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| Authors: | Esteban Marcellin Christian W Gruber Colin Archer David J Craik Lars K Nielsen |
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| Institution: | (1) Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Queensland, QLD 4072, Australia;(2) Institute for Molecular Bioscience (IMB), University of Queensland, Queensland, QLD 4072, Australia;(3) Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Waehringer Str. 13a, A-1090 Vienna, Austria |
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| Abstract: | Background
Streptococcus equi subsp. zooepidemicus (S. zooepidemicus) is a commensal of horses and an opportunistic pathogen in many animals and humans. Some strains produce copious amounts
of hyaluronic acid, making S. zooepidemicus an important industrial microorganism for the production of this valuable biopolymer used in the pharmaceutical and cosmetic
industry. Encapsulation by hyaluronic acid is considered an important virulence factor in other streptococci, though the importance
in S. zooepidemicus remains poorly understood. Proteomics may provide a better understanding of virulence factors in S. zooepidemicus, facilitate the design of better diagnostics and treatments, and guide engineering of superior production strains. |
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