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Vasoactive intestinal peptide inhibits TNF-α-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands |
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| Authors: | Mario Calafat Luciana Larocca Valeria Roca Vanesa Hauk Nicolás Pregi Alcira Nesse and Claudia Pérez Leirós |
| Institution: | 1.Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 4° piso, 1428, Buenos Aires, Argentina;2.Consejo Nacional de Investigaciones Científicas y Técnicas, Avda. Rivadavia 1917, CP C1033AAJ, Buenos Aires, Argentina |
| Abstract: | IntroductionThe role of apoptotic secretory epithelium as a pro-inflammatory triggering factor of exocrine dysfunction is currently explored in Sjogren's syndrome patients and in the nonobese diabetic (NOD) mouse model. Vasoactive intestinal peptide (VIP) has anti-inflammatory effects in various models of chronic inflammation. Our goal was to analyse the effect of TNF-α on apoptotic mediators in isolated acinar cells from NOD submandibular gland and their modulation by VIP. |
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