Influences of Flavonoids on Erythrocyte Membrane and Metabolic Implication Through Anionic Exchange Modulation |
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Authors: | Davide Barreca Giuseppina Laganà Ester Tellone Silvana Ficarra Ugo Leuzzi Antonio Galtieri Ersilia Bellocco |
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Institution: | (1) Organic and Biological Chemistry Department, University of Messina, Messina, Italy; |
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Abstract: | The antioxidative activity of some natural flavonoids was analyzed against the stable free radical 2,2-diphenyl-1-picryhydrazyl.
The results indicate that the scavenging power of the tested flavonols is higher than that of the synthetic antioxidants butylated
hydroxyanisole and butylated hydroxytoluene; instead, the flavanones show little activity, as indicated by efficient concentration
(EC50) values. Flavonoid autoxidation and interaction with Fe2+ and hydrogen peroxide were tested using erythrocyte membranes as a model. The results show that some compounds, like hesperetin,
evidence a pro-oxidant activity higher than the ascorbic acid/iron reference system. The compounds with strong oxidative capability
do not only influence cellular redox balance but also activate caspase-3, producing lactate dehydrogenase release and enhancing
anionic exchange at the level of band 3 protein. |
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Keywords: | |
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