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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Authors:Tao Che  Susruta Majumdar  Saheem A. Zaidi  Pauline Ondachi  John D. McCorvy  Sheng Wang  Philip D. Mosier  Rajendra Uprety  Eyal Vardy  Brian E. Krumm  Gye Won Han  Ming-Yue Lee  Els Pardon  Jan Steyaert  Xi-Ping Huang  Ryan T. Strachan  Alexandra R. Tribo  Gavril W. Pasternak  Bryan L. Roth
Affiliation:1. Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;2. Molecular Pharmacology Program and Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;3. Department of Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA;4. Center for Organic and Medicinal Chemistry, Research Triangle Institute, Research Triangle Park, NC 27709, USA;5. Department of Medicinal Chemistry and Institute for Structural Biology, Drug Discovery and Development, Virginia Commonweath University, Richmond, VA 23298, USA;6. Department of Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA;7. School of Molecular Sciences, Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA;8. Institute of Natural Resources and Environmental Audits, Nanjing Audit University, Nanjing, China;9. Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium;10. VIB-VUB Center for Structural Biology, VIB, 1050 Brussels, Belgium;11. National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;12. Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Abstract:
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  • Keywords:GPCR  opioid receptor  addiction  crystallography  active state  nanobody  structure-function  morphinan
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