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Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor
Authors:Matthew T Eddy  Ming-Yue Lee  Zhan-Guo Gao  Kate L White  Tatiana Didenko  Reto Horst  Martin Audet  Pawel Stanczak  Kyle M McClary  Gye Won Han  Kenneth A Jacobson  Raymond C Stevens  Kurt Wüthrich
Institution:1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA;3. Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA;4. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT 06340, USA;5. Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:GPCR  allosteric modulation  NMR  signaling  membrane protein  G protein-coupled receptor  nuclear magnetic resonance
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