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BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis
Authors:Eva Kaufmann  Joaquin Sanz  Jonathan L Dunn  Nargis Khan  Laura E Mendonça  Alain Pacis  Fanny Tzelepis  Erwan Pernet  Anne Dumaine  Jean-Christophe Grenier  Florence Mailhot-Léonard  Eisha Ahmed  Jad Belle  Rickvinder Besla  Bruce Mazer  Irah L King  Anastasia Nijnik  Clinton S Robbins  Maziar Divangahi
Institution:1. Meakins-Christie Laboratories, Department of Medicine, Department of Microbiology and Immunology, Department of Pathology, McGill International TB Centre, McGill University Health Centre, Montreal, QC H4A 3J1, Canada;2. Department of Biochemistry, Faculty of Medicine, Université de Montréal, QC H3T 1J4, Canada;3. Department of Genetics, CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada;4. Department of Physiology, Complex Traits Group, McGill University, Montreal, QC H3G 0B1, Canada;5. Department of Immunology, University of Toronto, Toronto, ON M5G 1L7, Canada;6. Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1C5, Canada
Abstract:
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  • Keywords:trained immunity  stem cells  epigenetic reprogramming  macrophages  mycobacterium tuberculosis  BCG
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