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Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Authors:Anette Christ  Patrick Günther  Mario AR Lauterbach  Peter Duewell  Debjani Biswas  Karin Pelka  Claus J Scholz  Marije Oosting  Kristian Haendler  Kevin Baßler  Kathrin Klee  Jonas Schulte-Schrepping  Thomas Ulas  Simone JCFM Moorlag  Vinod Kumar  Min Hi Park  Leo AB Joosten  Laszlo A Groh  Eicke Latz
Institution:1. Institute of Innate Immunity, University Hospital Bonn, University of Bonn, 53127 Bonn, Germany;2. Department of Infectious Diseases & Immunology, UMass Medical School, Worcester, MA 01605, USA;3. Department for Genomics & Immunoregulation, and Myeloid Cell Biology, Life and Medical Sciences Institute (LIMES), University of Bonn, 53115 Bonn, Germany;4. Center of Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80337 Munich, Germany;5. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;6. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands;7. Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands;8. Lipid Metabolism Unit, Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;9. Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, 77845 College Station, TX, USA;10. Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway;11. German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany
Abstract:
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  • Keywords:trained immunity  innate immune memory  sterile inflammation  granulocyte macrophage progenitors  Western diet feeding  epigenetic reprogramming  NLRP3 inflammasome  atherosclerosis  non-communicable diseases  ASC
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