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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Authors:Rui Su  Lei Dong  Chenying Li  Sigrid Nachtergaele  Mark Wunderlich  Ying Qing  Xiaolan Deng  Yungui Wang  Xiaocheng Weng  Chao Hu  Mengxia Yu  Jennifer Skibbe  Qing Dai  Dongling Zou  Tong Wu  Kangkang Yu  Hengyou Weng  Huilin Huang  Jianjun Chen
Affiliation:1. Department of Cancer Biology, University of Cincinnati, Cincinnati, OH 45219, USA;2. Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA;3. Key Laboratory of Hematopoietic Malignancies, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, China;4. Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;5. College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Hubei, Wuhan 430072, China;6. Gehr Family Center for Leukemia Research, City of Hope, 1500 E. Duarte Rd., Duarte, CA 91010, USA;7. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA;8. Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45267, USA;9. School of Pharmacy, China Medical University, Shenyang, Liaoning 110001, China;10. Depart of Gynecologic Oncology, Chongqing Cancer Institute and Hospital and Cancer Center, Chongqing 400030, China
Abstract:
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  • Keywords:R-2HG  FTO  MYC  CEBPA  IDH mutation  S-2HG  leukemia  glioma
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