磁性纳米粒子作用于肝癌细胞的生物学效应的研究进展

磁性纳米粒子,是一类智能型的纳米材料,因其特有的性质,被广泛应用于生物医学领域,在肝癌的治疗方面也有大量的实验性研究和成果。研究和探索磁性纳米粒子治疗肝癌的新方法和途径,有着很大的现实意义。本文就磁性纳米粒子作用于肝癌细胞的生物学效应的研究现状和进展进行总结整理,从三个方面进行了综述:磁性纳米粒子直接作用于肝癌细胞,探索磁性纳米粒子的生物相容性、在肝癌细胞的分布方式以及磁性纳米粒子本身对肝癌细胞的生物学效应的影响;磁性纳米粒子协同外加磁场(稳恒磁场、极低频交变磁场和高频交变磁场)作用于肝癌细胞;磁性纳米粒子外加修饰(磁性白蛋白纳米颗粒、纳米磁流体、磁性脂质体等),作为药物载体作用于肝癌细胞。

The Research Progress of Biology Effects of Magnetic Nanoparticles on Hepatoma Cells

Magnetic nanoparticle is a kind of intelligent nano material. It is widely used in biomedical fields because of its unique properties. A large number of experimental research have been done in the treatment of liver cancer. Exploring the new ways of magnetic nanoparticles in liver cancer treatment has great practical significance. This article summarizes the current research state and progress of magnetic nanoparticles in hepatoma cells biology and reviews them from three aspects: Directly acting on the liver cancer cells, the biocompatibility, distribution and biological effects in liver cancer cells of magnetic nanoparticles are explored; Magnetic nanoparticles and external magnetic field (static magnetic field, SMF, extremely low frequency alternating magnetic field and high-frequency alternating magnetic field, EMF) synergistically act on hepatoma cells; Plus modified magnetic nanoparticles (magnetic albumin nanoparticles, nano-magnetic fluid, magnetic liposomes, etc.) act on hepatoma cells as drug carriers.