Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: Comparisons between acute drug treatment and a drug challenge in sensitized animals |
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Authors: | Eileen J Curran Huda Akit Stanley J Watson |
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Institution: | (1) Mental Health Research Institute, The University of Michigan, 205 Zina Pitcher Place, 48109-0720 Ann Arbor, MI |
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Abstract: | Amphetamine-, cocaine-, and morphine-induced c-fos expression patterns were examined following an injection protocol that has previously been shown to produce behavioral sensitization
and enhanced dopamine release in the striatal complex. Drug-specific c-fos patterns were observed in both acute and sensitization injection paradigms. A sensitization pretreatment schedule did, however,
alter the c-fos expression patterns induced by all the drugs in the caudate putamen, nucleus accumbens, and the cerebral cortex. In some
striatal and cortical regions, there was an increase or recruitment of cells expressing c-fos whereas in others there was an apparent decrease or inhibition. The somatosensory cortex was one area where pretreatment
with all three drugs increased c-fos expression. The results suggest that the neuronal networks that are modulated by systemic drug injections in the sensitized
animal differ from those affected by the initial drug exposure; areas of overlap may indicate common ‘sensitization’ circuits.
Special issue dedicated to Dr. Eric J. Simon. |
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Keywords: | Striatum somatosensory cortex amphetamine cocaine morphine |
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