Cancer chemopreventive effects of starfish polysaccharide in human breast cancer cells |
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Authors: | Kyu-Shik Lee Jin-Sun Shin Kyung-Soo Nam |
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Institution: | (1) Gude Lab, Advanced Centre for Treatment, Research & Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, 410210, India; |
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Abstract: | We investigated the effect of starfish (Asterina pectinifera) polysaccharide on the progression and metastasis of human breast cancer cells. At a concentration range of 10 ∼ 120 μg/mL
the polysaccharide significantly decreased the expression of cyclooxygenase-2 (COX-2) protein induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and of aromatase mRNA. In a wound healing assay, motility of human MDA-MB-231 breast
cancer cells was prevented by the polysaccharide in a dose-dependent manner. These results indicate that starfish polysaccharide
can prevent breast cancer progression and metastasis by decreasing prostaglandin E2 and estrogen biosynthesis by COX-2 and aromatase, and by inhibiting cell motility. This report presents information regarding
the effectiveness of starfish polysaccharide as a chemopreventive agent against breast cancer. |
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