Changes in expression of the genes for chemokines,cytokines, and their receptors in response to selank and its fragments |
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| Authors: | T. A. Kolomin M. I. Shadrina P. A. Slominsky S. A. Limborska N. F. Myasoedov |
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| Affiliation: | 1.Institute of Molecular Genetics,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | A study of the immunomodulating effect of selank showed that both the total peptide and its fragment significantly change the expression of the genes for chemokines, cytokines, and their receptors in mouse spleen 6 and 24 h after single administration. Changes in the mRNA level of the majority of the genes under study were observed after the administration of Gly-Pro, which was earlier identified as a selank pharmacophore, a minimum fragment with anitiviral activity. |
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