Potential of Chromium(III) Picolinate for Reproductive or Developmental Toxicity Following Exposure of Male CD-1 Mice Prior to Mating |
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Authors: | DeAna McAdory Nicholas R Rhodes Felicia Briggins Melissa M Bailey Kristin R Di Bona Craig Goodwin John B Vincent Jane F Rasco |
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Institution: | (1) Department of Chemistry, The University of Alabama, Box 870336, Tuscaloosa, AL 35487–0336, USA;(2) Department of Biological Sciences, The University of Alabama, Box 870344, Tuscaloosa, AL 35487–0344, USA;(3) Department of Biological Sciences, Emporia State University, Emporia, KS 66801, USA; |
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Abstract: | Chromium(III) picolinate, Cr(pic)3], is a commonly used nutritional supplement in humans, which has also been approved for use in animals. Health concerns have
arisen over the use of Cr(pic)3]. At high Cr(pic)3] doses, developmental toxicity tests in female mice have shown a higher litter incidence of split cervical arch in exposed
fetuses, but this was not consistently reproducible. In the current study, male CD-1 mice were used to further assess the
potential for reproductive or developmental toxicity. Four weeks prior to mating, the males were fed a diet providing 200 mg/kg/day
Cr(pic)3] for comparison with untreated controls. Females were not treated. Each male was mated with two females, which were sacrificed
on gestation day 17, and their litters were examined for adverse effects. Mating and fertility indices were not significantly
altered by treatment. Male exposure to Cr(pic)3] also had no effect on prenatal mortality, fetal weight, or gross or skeletal morphology. These results suggest that paternal
dietary exposure to chromium(III) picolinate has little potential for adverse reproductive effects, even at exposure levels
considerably higher than expected human exposures from nutritional supplements (1 mg of Cr per day or less). |
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