Molecular studies on trypanothione reductase, a target for antiparasitic drugs |
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Authors: | C Walsh M Bradley K Nadeau |
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Affiliation: | Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115. |
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Abstract: | Trypanosoma and Leishmania are parasitic protozoa that cause a variety of diseases, which include African sleeping sickness and oriental sore. Attempts to determine pharmaceutically exploitable differences between host and parasite biochemistry have identified the unique trypanothione pathway as a possible target. This pathway includes the enzyme trypanothione reductase, the parasite analogue of glutathione reductase. |
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