cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai |
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| Affiliation: | 1. Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, 69120 Heidelberg, Germany;2. Institute for Immunology, Technische Universität Dresden, Medical Faculty Carl Gustav Carus, 01307 Dresden, Germany;1. Department of Vegetative Physiology, Eberhad Karls University, Wilhelmstr. 56, D-72074 Tübingen, Germany;2. German Center for Neurodegenerative Diseases, Research Site Tübingen, Germany;3. Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Germany;4. Department of Neurology and Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden, Germany & DZNE, German Center for Neurodegenerative Diseases, Research Site Dresden, Germany;5. Department of Biochemistry, University of Crete Medical School, Heraklion, Greece;1. Kuang Yaming Honors School, Nanjing University, Nanjing 210023, People''s Republic of China;2. Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, People''s Republic of China;3. State Key Laboratory of Scientific and Engineering Computing, National Center for Mathematics and Interdisciplinary Sciences, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, People''s Republic of China;4. Institute for Computational Molecular Science, Temple University, Philadelphia, PA 19122, USA;5. CAEP Software Center for High Performance Numerical Simulation, Beijing 100088, People''s Republic of China;6. Institute for Brain Sciences, Nanjing University, Nanjing 210023, People''s Republic of China |
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| Abstract: | Calcium and cyclic AMP form the cornerstones of two ancient signaling systems represented in nearly every kingdom of life. Not surprisingly, these old and ubiquitous messenger molecules have co-evolved multiple means to regulate one another. Zhang et al. describe a new twist on this theme related to the intimate union between the calcium-activated adenylyl cyclase, AC8, and the store-operated Ca2+ channel, Orai1. |
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| Keywords: | Adenylyl cyclase Cyclic AMP Calcium channels Electrophysiology Patch clamp |
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