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Slaying a giant: Structures of calmodulin and protein kinase a bound to the cardiac ryanodine receptor |
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| Institution: | 1. Departments of Physiology, Perelman School of Medicine University of Pennsylvania Philadelphia, PA 19104-6085, United States;2. Cell and Developmental Biology, Perelman School of Medicine University of Pennsylvania Philadelphia, PA 19104-6085, United States;3. Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Elche, 03202 Alicante, Spain;4. Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 1027 Santiago, Chile;5. Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, 03080 Alicante, Spain |
| Abstract: | Ryanodine Receptors are Ca2+ release channels expressed in the Endoplasmic and Sarcoplasmic Reticulum membranes. Gong et al 1] reported cryo-EM structures of the cardiac RyR2 complexed to Calmodulin, which can downregulate channel opening. Haji-Ghassemi et al 2] report crystal structures of an RyR2 domain with PKA, a kinase promoting channel opening. |
| Keywords: | Muscle excitation-contraction coupling Cryo-electron microscopy X-ray crystallography Ryanodine receptor cAMP-dependent protein kinease Calcium release channel |
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