Emerging structural biology of TRPM subfamily channels |
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| Affiliation: | 1. School of Basic Medical Sciences, Nanchang University, Nanchang, 330031, Jiangxi, China;2. Queen Mary School, Medical Department, Nanchang University, Nanchang, 330031, Jiangxi, China;3. School of Pharmacy, Nanchang University, Nanchang, 330031, Jiangxi, China;4. School of Nursing, Nanchang University, Nanchang, 330031, Jiangxi, China;5. The First Affiliated Hospital of Nanchang University, Nanchang, 330031, Jiangxi, China;6. College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, Jiangxi, China;7. Key Laboratory of Cerebrovascular Pharmacology of Jiangxi Province, Gannan Medical University, Ganzhou, 341000, Jiangxi, China;1. Department of General Surgery, The Fourth Hospital of Changsha, Hunan Normal University, Changsha, 410006, People''s Republic of China;2. Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410078, People''s Republic of China |
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| Abstract: | TRPM family (Transient receptor potential channels, M for melastatin) is a group of intrinsic plasma membrane ion channels which are widely expressed throughout human body. It has been identified as a potent entry point of working desperate diseases out in a new way with newfangled ideas and safer technological means. In our review, we discussed the common and unique properties of TRPM family with the elaborate narrate in their overall structures, different states and the underlying activation mechanism. Thus, this review can help to consummate the limited work of TRPM family and provide novel therapeutic targets of certain diseases. |
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| Keywords: | TRPM channel Cryo-EM Structure Ion permeation Gating mechanism |
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