ORAI channels in cellular remodeling of cardiorespiratory disease |
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Affiliation: | 1. Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nové Hrady CZ-373 33, Czech Republic;2. Institute for Biophysics, Johannes Kepler University Linz, A-4040 Linz, Austria;3. Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria;4. College of Biomedical Sciences, Larkin University, Miami, FL 33169, United States |
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Abstract: | Cardiorespiratory disease, which includes systemic arterial hypertension, restenosis, atherosclerosis, pulmonary arterial hypertension, asthma, and chronic obstructive pulmonary disease (COPD) are highly prevalent and devastating diseases with limited therapeutic modalities. A common pathophysiological theme to these diseases is cellular remodeling, which is contributed by changes in expression and activation of ion channels critical for either excitability or growth. Calcium (Ca2+) signaling and specifically ORAI Ca2+ channels have emerged as significant regulators of smooth muscle, endothelial, epithelial, platelet, and immune cell remodeling. This review details the dysregulation of ORAI in cardiorespiratory diseases, and how this dysregulation of ORAI contributes to cellular remodeling. |
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Keywords: | ORAI STIM SOCE CRAC ARC Remodeling Hypertension Atherosclerosis Restenosis Pulmonary hypertension Asthma COPD |
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