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Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria |
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| Authors: | Kane John L Hirth Bradford H Liang Beirong Gourlie Brian B Nahill Sharon Barsomian Gary |
| Institution: | Genzyme Drug Discovery and Development, Genzyme Corp., Cambridge MA 02139, USA |
| Abstract: | Ureas of 5-aminopyrazole and 2-aminothiazole emerged as lead compounds from a high-throughput screen assaying the growth of Staphylococcus aureus. Structure–activity relationships were developed for each compound series. Several compounds were also tested for activity against drug resistant strains of S. aureus in vivo. |
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