| 紫杉醇诱导凋亡的信号传导通路及与凋亡相关的基因和蛋白 |
| |
| 引用本文： | 刘丹,康宏,孙传真,肖野,赵凯. 紫杉醇诱导凋亡的信号传导通路及与凋亡相关的基因和蛋白[J]. 生物工程学报, 2013, 29(2): 153-160 |
| |
| 作者姓名： | 刘丹 康宏 孙传真 肖野 赵凯 |
| |
| 作者单位： | 黑龙江大学生命科学学院微生物黑龙江省高校重点实验室农业微生物技术教育部工程研究中心,黑龙江哈尔滨,150080 |
| |
| 基金项目： | 国家自然科学基金(No.30970090);教育部新世纪优秀人才支持计划,中国博士后科学基金项目(No.20090450136);哈尔滨市科技创新人才研究专项资金项目(No.2010RFQXS043);黑龙江省普通高等学校新世纪优秀人才培养计划(No.1251-NCET-005);黑龙江省教育厅科学技术研究项目(No.11551377)资助~~ |
| |
| 摘 要： | 紫杉醇对临床多种恶性肿瘤都有疗效,并具广阔的市场应用前景,其抗癌机制是致使肿瘤细胞发生细胞周期阻滞而凋亡.作者结合课题组多年来的研究,对紫杉醇诱导凋亡过程中的信号通路、相关基因及蛋白进行介绍,包括微生物发酵生产紫杉醇的基因、细胞周期蛋白、端粒酶等.
|
| 关 键 词： | 紫杉醇 细胞凋亡 信号传导 凋亡基因 相关蛋白 |
| 收稿时间： | 2012-10-10 |
Paclitaxel induced apoptotic genes and pathways alterations: a review |
| |
| Dan Liu,Hong Kang,Chuanzhen Sun,Ye Xiao and Kai Zhao. Paclitaxel induced apoptotic genes and pathways alterations: a review[J]. Chinese journal of biotechnology, 2013, 29(2): 153-160 |
| |
| Authors: | Dan Liu Hong Kang Chuanzhen Sun Ye Xiao Kai Zhao |
| |
| Affiliation: | Laboratory of Microbiology, College of Life Science, Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, Heilongjiang, China;Laboratory of Microbiology, College of Life Science, Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, Heilongjiang, China;Laboratory of Microbiology, College of Life Science, Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, Heilongjiang, China;Laboratory of Microbiology, College of Life Science, Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, Heilongjiang, China;Laboratory of Microbiology, College of Life Science, Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150080, Heilongjiang, China |
| |
| Abstract: | Taxol has clinical efficacy on many malignant tumors, thus having a good market prospects. The anti-cancer mechanism of taxol is to arrest the cell cycle of tumor cells, leading to apoptosis. Based on our research over the years, we reviewed the latest developments in signaling pathways, the effects of related genes and proteins on apoptosis during paclitaxel-induced apoptosis process, including the paclitaxel-producing gene in microbial fermentation process, cyclin, telomerase of apoptosis. |
| |
| Keywords: | paclitaxel apoptosis signaling transduction apoptosis gene associated protein |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《生物工程学报》浏览原始摘要信息 |
|
点击此处可从《生物工程学报》下载全文 |
|
