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Activity of some hepatic enzymes in schistosomiasis and concomitant alteration of arylsulfatase B
Authors:Balbaa Mahmoud  El-Kersh Mohamed  Mansour Hamdy  Yacout Galila  Ismail Mohamed  Malky Ahmed  Bassiouny Khaled  Abdel-Monem Nihad  Kandeel Kamal
Affiliation:Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt. m_balbaa@hotmail.com
Abstract:The levels of arylsulfatases A and B, alpha-amylase, aspartate transcarbamylase, and gamma-glutamyl transpeptidase were investigated during the infection of mice with schistosoma mansoni. This infection caused a significant (p < 0.001) increase in the activity of hepatic arylsulfatase B (ASB), aspartate transcarbamylases and gamma-glutamyl transpeptidase. A non-significant difference occurred for alpha-amylase (p < 0.3) and arylsulfatase A (p > 0.5) when compared to the control. The specific activity of hepatic ASB was progressively increased with the progression of the Schistosoma-infection. Moreover, the kinetic studies of hepatic ASB in Schistosoma-infection showed that a slight decrease in the value of K(m) and about a 40% increase in V(max) when compared to the control. In addition, the pH optimum of hepatic ASB was altered from 6 to 7 as a result of schistosomiasis. These observations suggest that there are schistosomiasis-associated changes of the catalytic and kinetic properties of hepatic ASB.
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