疱疹病毒膜融合的分子机制

囊膜病毒与宿主细胞的膜融合是病毒入侵宿主细胞的重要过程，这一过程涉及到病毒囊膜表面糖蛋白与宿主细胞表面受体之间的相互作用和构象变化．疱疹病毒有多个糖蛋白及不同类型的细胞作用受体，相应的受体-糖蛋白复合体构成方式也有多种，其引致的膜融合机制被认为是目前病毒融合机制研究中最复杂的，近年来被广泛研究并取得突破性进展．从病毒糖蛋白与相应受体的结构与功能、受体-糖蛋白复合体的形成与入侵途径，以及膜融合模式几个方面，全面综述疱疹病毒膜融合的分子机制，并展望了未来研究趋势．

The Molecular Mechanism of Herpesvirus Membrane Fusion

Membrane fusion between the viral envelope and host cell membrane is a key step for an enveloped virus entering into the host cell. The process involves intricate interactions between and conformational changes of viral envelope glycoproteins and corresponding cellular receptors. Herpesvirus contains many glycoproteins and different types of cellular receptors, the transformable receptor-glycoprotein complex constitutes a multipartite entry-fusion system. The molecular mechanisms of membrane fusion are generally regarded as the one of the most challenging issues in the study of enveloped virus. Much progress has been made recently in achieving a substantially improved knowledge base of this subject. A comprehensive review was presented on the structures and functions of important viral glycoproteins and receptors, formation of a receptor-glycoprotein complex during herpesvirus entry, and associated pathways. Detailed models of viral membrane fusion are also given. In addition, the prospect of future research is addressed.