原核生物的蛋白质翻译后修饰

蛋白质翻译后修饰是调节蛋白质生物学功能的关键步骤之一,是蛋白质动态反应和相互作用的一个重要分子基础,同时,它也是细胞信号网络调控的重要靶点.目前,蛋白质翻译后修饰已经成为国际上蛋白质研究的一个极其重要的热点.在原核生物生命活动中,蛋白质的翻译后修饰具有十分重要的作用,如参与细胞信号传导、物质的代谢、蛋白质的降解、致病微生物的致病过程等.综述了经典原核生物蛋白质翻译后修饰的种类、机制和功能,同时介绍了最近发现的原核生物的全局性乙酰化修饰以及结核分枝杆菌中类泛素化修饰.

Protein post-translational modification in prokaryotes

Post-translational modification of proteins is a key step in the process of regulating their biological functions and it's an important molecular basis in the dynamic response and interaction of proteins, meanwhile, it can be considered as important targets to regulate the cell signaling networks. At present, post-translational modification of protein has become a critical area in the research of proteins. In prokarytes, post-translational modification of proteins can play a crucial role in the life activities, such as cell signal transduction, metabolism, protein degradation, pathogenicity of pathogenic microorganisms and so on. The types, mechanisms and functions of the classical post-translational modification of proteins in prokaryotes were summarized and the recently discovered global acetylation in Salmonella enterica, as well as the ubiquitin-like modification in Mycobacterium tuberculosis, were also introduced.