HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium,and at the maternal-fetal interface during early pregnancy |
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| Authors: | Marissa A Bowden Ying Li Yi-Xun Liu Jock K Findlay Lois A Salamonsen Guiying Nie |
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| Affiliation: | (1) Prince Henry's Institute of Medical Research, Monash University, PO Box 5152, 3168 Clayton, Victoria, Australia;(2) Department of Obstetrics & Gynaecology, Monash University, Clayton, Victoria, 3168, Australia;(3) State Key Laboratory for Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100080, PR China |
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| Abstract: | Background HTRA3 is a recently identified member of the mammalian serine protease family HTRA (high temperature requirement factor A). In both the rodent and the human HTRA3 is transcribed into two mRNA species (long and short) through alternative splicing. We have previously shown that HTRA3 is expressed in the mature rat ovary and may be involved in folliculogenesis and luteinisation. HTRA3 is also upregulated during mouse and human placental development. The current study investigated whether HTRA3 is also localised in the primate ovary (rhesus monkey n = 7). In addition, we examined the non-pregnant rhesus monkey endometrium (n = 4) and maternal-fetal interface during early pregnancy (n = 5) to further investigate expression of HTRA3 in primate endometrium and placentation. |
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