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The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target
Affiliation:1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA;2. Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;3. Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA;4. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA;5. Division of Infectious Diseases, John T. Milliken Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Abstract:
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  • Keywords:severe fever with thrombocytopenia syndrome virus  Heartland virus  endonuclease  X-ray structure  antiviral target  mass spectrometry  Baloxavir
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