Revisiting caspases in sepsis |
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Authors: | M Aziz A Jacob P Wang |
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Institution: | 1.Center for Translational Research, The
Feinstein Institute for Medical Research, Manhasset, NY, USA;2.Department of Surgery, Hofstra North
Shore-LIJ School of Medicine, Manhasset, NY, USA |
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Abstract: | Sepsis is a life-threatening illness that occurs due to an abnormal host immune
network which extends through the initial widespread and overwhelming inflammation,
and culminates at the late stage of immunosupression. Recently, interest has been
shifted toward therapies aimed at reversing the accompanying periods of immune
suppression. Studies in experimental animals and critically ill patients have
demonstrated that increased apoptosis of lymphoid organs and some parenchymal tissues
contributes to this immune suppression, anergy and organ dysfunction. Immediate to
the discoveries of the intracellular proteases, caspases for the induction of
apoptosis and inflammation, and their striking roles in sepsis have been focused
elaborately in a number of original and review articles. Here we revisited the
different aspects of caspases in terms of apoptosis, pyroptosis, necroptosis and
inflammation and focused their links in sepsis by reviewing several recent findings.
In addition, we have documented striking perspectives which not only rewrite the
pathophysiology, but also modernize our understanding for developing novel
therapeutics against sepsis. |
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