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Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins
Institution:1. Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA;2. Tufts Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA;3. Department of Neuroscience, U.S. Army Medical Research Institute of Chemical Defense, Gunpowder, MD 21010, USA;4. NE-CAT, Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory, Argonne, IL 60439, USA;5. The Division of Molecular and Translational Sciences, United States Army Medical Research Institute for Infectious Diseases, Fort Detrick, MD 21702, USA
Abstract:
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  • Keywords:botulinum neurotoxin  single-domain antibody  VHH  neutralizing epitope  bifunctional antibody  antitoxin  structure-based design
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