Anti-fungal resistance in candida isolated from oral and diaper rash candidiasis in neonates |
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| Authors: | Jasem Mohamadi Mahsa Motaghi Jafar panahi Mohamad Reza Havasian Ali Delpisheh Mitra Azizian Iraj Pakzad |
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| Institution: | 1.Department pediaterics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran;2.Department Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran;3.Student research of committee, Ilam University of Medical Sciences, Ilam/ Iran;4.Department Epidemiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam/ Iran;5.Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam/ Iran |
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| Abstract: | The purpose of the present study is to evaluate the sensitivity of Candida species isolated from oral candidiasis and diaper
dermatitis infections in children. The children referring to private and public clinics in Ilam, Iran were exmined for oral candidiasis
and diaper dermatitis. In this study, 248 oral candidiasis and diaper dermatitis samples were collected and cultured.Candida
species were identified by using standard methods. Resistance and sensitivity to amphotericin B, nystatin, ketoconazole,
fluconazole, itraconazole, clotrimazole, and posaconazole were determined using the CLSI M44-A standard disk diffusion method.
From the 248 studied samples, 149 were positive for Candida, among which the Candida albicans was the most prevalent (64.4%).
The resistance of different Candida species to nystatin, itraconazole, fluconazole, ketoconazole, clotrimazole, voriconazole, and
posaconazole were 4, 43, 34.2, 34.9, 21.5, 6, and 6.7%, respectively. No resistance to amphotericin B was observed. Considering
rather low resistance to nystatin, this drug is the best choice for oral candidiasis and diaper dermatitis. |
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| Keywords: | Drug resistance Oral candidiasis Diaper dermatitis |
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