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High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis
Affiliation:1. UCLA Department of Molecular Biology Interdepartmental Program, UCLA, Los Angeles, CA 90095, USA;2. UCLA Medical Scientist Training Program, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA;3. UCLA Children’s Discovery and Innovation Institute, Mattel Children’s Hospital UCLA, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA;4. Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA;5. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA;6. UCLA Department of Molecular & Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA;7. California NanoSystems Institute, UCLA, Los Angeles, CA 90095, USA;8. Eli and Edythe Broad Stem Cell Research Center, UCLA, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:homeostasis  drug screen  Wnt  beta-catenin  lung  premalignancy  airway stem cell
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