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NAD+ Repletion Rescues Female Fertility during Reproductive Aging
Affiliation:1. School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia;2. School of Women’s and Children’s Health, UNSW Sydney, Sydney, NSW, Australia;3. Human Reproduction Unit, Kolling Institute, Sydney Medical School, University of Sydney, St Leonards, NSW, Australia;4. ARC Centre of Excellence in Nanoscale Biophotonics, UNSW Sydney, NSW, Australia;5. Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston MA, USA;6. Jumpstart Fertility Pty Ltd., Sydney, NSW, Australia;7. Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia;8. Graduate Entry Medical School, University of Limerick, Limerick, Republic of Ireland;9. Neuroscience Research Australia, Randwick, NSW, Australia;10. Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan;11. ANZAC Medical Research Institute, University of Sydney, Concord, NSW, Australia;12. Christopher Chen Oocyte Biology Laboratory, University of Queensland Centre for Clinical Research, Royal Brisbane & Women’s Hospital, Herston, QLD, Australia
Abstract:
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  • Keywords:oocyte  nicotinamide adenine dinucleotide (NAD+)  nicotinamide mononucleotide (NMN)  SIRT2  female fertility  infertility  reproductive aging  aging  embryo development  in vitro fertilization
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