MTM-6, a Phosphoinositide Phosphatase,is Required to Promote Synapse Formation in Caenorhabditis elegans
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| Authors: | Vivian R. Ericson Kerri A. Spilker Madina S. Tugizova Kang Shen |
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| Affiliation: | Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, California, United States of America.; University of Texas Medical Branch, United States of America, |
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| Abstract: | Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6 shows relative specificity for EGL-20 over the other Wnt ligands. We suggest that the ability of MTM-6 to regulate EGL-20 secretion is a function of its expression pattern. We conclude that regulation of secretion of different Wnt ligands can use different components. Additionally, we present a novel neuronal function for MTM-6. |
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