Rodent tumor profiles, Salmonella mutagenicity and risk assessment |
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Authors: | R Benigni |
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Institution: | Istituto Superiore di Sanità, Laboratorio Tossicologia Comparata ed Ecotossicologia, Rome, Italy. |
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Abstract: | The tumorigenesis profiles of 116 chemicals, which proved to induce cancer in the NCI/NTP experimentation, were studied by multivariate data analysis methods. Three main patterns of tumor induction were evident. One chemical (benzene) was not classifiable in any of the 3 clusters of chemicals. The carcinogen classes based on patterns of tumor induction did not reflect a repartition between Ames-positive and Ames-negative chemicals. Therefore any classification of carcinogens as either 'primary' (genotoxic, hence assumed to pose a greater risk) or 'secondary' (presumably carcinogenic via non-genotoxic mechanisms) would seem to be a subject for research and speculation, and, for the present, an unsuitable basis for risk assessment. |
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