The scavenging of superoxide radicals promotes apoptosis induced by a novel cell-permeable fusion protein,sTRAIL:FeSOD,in tumor necrosis factor-related apoptosis-inducing ligand-resistant leukemia cells |
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| Authors: | Hongyun Tang Yong Qin Jianyong Li Xingguo Gong |
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| Affiliation: | (1) Institute of Biochemistry, Zhejiang University, Hangzhou, 310058, PR China;(2) Institute of Biochemistry, College of Life Sciences, Zhejiang University, Zijingang campus, Room 345, Hangzhou, PR China |
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| Abstract: | Background Many cancer cells develop resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, necessitating combination with chemotherapy, and normal cells manifest side effects due to the combined treatment regimen of TRAIL and chemotherapeutic drugs. A novel cancer therapy utilizing TRAIL is thus urgently needed. |
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