Iron deficiency depresses cell proliferation in hamster cheek pouch epithelium |
| |
| Authors: | A. W. Ranasinghe,N. W. Johnson,M. A. Scragg&dagger |
| |
| Affiliation: | Department of Oral Medicine, Dental School, University of Peradeniya, Peradeniya, Sri Lanka;*Department of Dental Sciences, Royal College of Surgeons of England, 35–43 Lincoln's Inn Fields, London WC2A 3PN, U.K.;†Department of Oral Pathology, The London Hospital Medical College, Turner Street, London E12AD, U.K. |
| |
| Abstract: | Abstract. Iron deficiency anaemia was induced in hamsters by feeding a low iron diet coupled with weekly bleeding. To assess cell proliferation, the stathmokinetic agent vinblastine sulphate was administered and cell birth rates were calculated from cumulative mitotic indices. The rate was significantly reduced in epithelium from iron-deficient animals. The uptake of tritiated thymidine ([3H]TdR) was also significantly reduced in these animals. Results of both stathmokinetic and labelling experiments indicate that cell production in the cheek pouch epithelium of iron-deficient animals is impaired. |
| |
| Keywords: | |
|
|
