Three genes for enzymes of the pyruvate dehydrogenase complex map to human chromosomes 3, 7, and X. |
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| Authors: | S Olson B J Song T L Huh Y T Chi R L Veech and O W McBride |
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| Institution: | National Institutes of Health 20892. |
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| Abstract: | The genes for three proteins of the pyruvate dehydrogenase (PDH) complex have been assigned to human chromosomes by Southern analysis of a panel of human-rodent somatic cell hybrid DNAs with cDNA probes for these genes. PDH-E1 alpha has been localized on human chromosome 3p13-q23. The assignments of lipoamide dehydrogenase(E3) and PDH-E1 alpha corrected] to chromosomes 7 and Xp, respectively, have been confirmed. Restrictive-fragment-length polymorphisms have been identified with E3, which will permit further localization of this gene by genetic linkage analysis. |
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