A test of the master gene hypothesis for interspersed repetitive DNA sequences |
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Authors: | Johnson Louise J Brookfield John F Y |
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Institution: | Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham, United Kingdom. |
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Abstract: | Many families of interspersed repetitive DNA elements, including human Alu and LINE (Long Interspersed Element) elements, have been proposed to have accumulated through repeated copying from a single source locus: the "master gene." The extent to which a master gene model is applicable has implications for the origin, evolution, and function of such sequences. One repetitive element family for which a convincing case for a master gene has been made is the rodent ID (identifier) elements. Here we devise a new test of the master gene model and use it to show that mouse ID element sequences are not compatible with a strict master gene model. We suggest that a single master gene is rarely, if ever, likely to be responsible for the accumulation of any repeat family. |
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Keywords: | SINE repetitive DNA master gene ID element BC1 |
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