Genetic variants in <Emphasis Type="Italic">FTO</Emphasis> associated with metabolic syndrome: a meta- and gene-based analysis |
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Authors: | Haina?Wang Shuqian?Dong Hui?Xu Jun?Qian Email author" target="_blank">Jingyun?YangEmail author |
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Institution: | College of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China. |
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Abstract: | The objective of this study was to examine the effect of genetic variants in fat mass and obesity associated (FTO) gene on metabolic syndrome (MetS). A systematic literature search was performed and random-effects meta-analysis was used
to evaluate genetic variants in FTO with MetS. A gene-based analysis was conducted to investigate the cumulative effects of genetic polymorphisms in FTO. A total of 18 studies from 13 published papers were included in our analysis. Random-effects meta-analysis yielded an estimated
odds ratio of 1.19 (95% CI 1.12–1.27; P = 1.38 × 10−7) for rs9939609, 1.19 (95% CI 1.05–1.35; P = 0.008) for rs8050136, and 1.89 (95% CI 1.20–2.96; P = 0.006) for rs1421085. The gene-based analysis indicated that FTO is strongly associated with MetS (P < 10−5). This association remains after excluding rs9939609, a SNP that was frequently reported to have strong association with
obesity and MetS. In this study, we concluded that the FTO gene may play a critical role in leading to MetS. Targeting this gene may provide novel therapeutic strategies for the prevention
and treatment of metabolic syndrome. |
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