Meta-analysis of association between cytokine gene polymorphisms and lung cancer risk |
| |
Authors: | Wen-jia Peng Qian He Jin-xia Yang Bing-xiang Wang Man-man Lu Song Wang Jing Wang |
| |
Institution: | Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China. |
| |
Abstract: | The aim of this study was to evaluate the association between various cytokine gene polymorphisms and lung cancer (LC) susceptibility.
We searched Pubmed, Elsevier Science Direct, China National Knowledge Infrastructure database, Chinese Biomedical database,
Google scholar. Totally, 20 studies involving 6,467 cases and 8,320 controls were included in the meta-analysis. The effects
of eight polymorphisms, i.e. TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T, COX-2 8473T/C, IL-10 1082G/A, IL-10 819C/T,
and IL-10 592C/A were evaluated. The combined odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate
the strength of the association in a fixed or random effect model. Heterogeneity and publication bias were also assessed.
We found a significant association between IL-10 polymorphism and LC. For IL-10 1082G/A, the overall ORs (95% CI) of the G
versus A, GG versus AA, and GG/GA versus AA were 2.35 (1.16–4.76), 2.07 (1.16–3.70) and 3.17 (1.31–7.68), respectively. For
IL-10 819C/T, the pooled ORs (95% CI) of the C versus T and CC versus TT were 1.27 (1.01–1.58) and 2.27 (1.32–3.89). For IL-10
592C/A, the comparison of subjects in the CC or CC/CA genotype versus AA homozygotes showed significant results (OR = 2.00,
95% CI: 1.24–3.23; OR = 1.80, 95% CI: 1.28–2.54). But, other gene polymorphisms did not reach statistical associations. IL-10
1082G/A, 819C/T and 592C/A polymorphisms might be risk factors for LC. TNF-α 308G/A, IL-6 174G/C, IL-1β 31T/C, IL-1β 511C/T,
COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC. Due to the limitation of the number of the
studies, we should take the conclusion with caution. While, further studies are necessary for more precise association. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|