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Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes |
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| Authors: | Kuroyanagi Kayo Kang Min-Sook Goto Tsuyoshi Hirai Shizuka Ohyama Kana Kusudo Tatsuya Yu Rina Yano Masamichi Sasaki Takao Takahashi Nobuyuki Kawada Teruo |
| Institution: | a Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan b Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, South Korea c Department of Citriculture, National Institute of Fruit Tree Science, Ministry of Agriculture, Forestry and Fisheries, Shimizu, Shizuoka 424-0292, Japan d ARKRAY Inc., Kyoto 601-8045, Japan |
| Abstract: | Citrus fruit compounds have many health-enhancing effects. In this study, using a luciferase ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-α and PPARγ. Auraptene induced up-regulation of adiponectin expression and increased the ratio of the amount of high-molecular-weight multimers of adiponectin to the total adiponectin. In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. Experiments using PPARγ antagonist demonstrated that these effects on regulation of adiponectin and MCP-1 expression were caused by PPARγ activations. The results indicate that auraptene activates PPARγ in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities. |
| Keywords: | Auraptene Adipocyte PPAR Adiponectine MCP-1 Inflammation Metabolic syndrome |
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