Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents |
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| Authors: | Sharma Pratibha Rane Nilesh Gurram V K |
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| Affiliation: | School of Chemical Sciences, Devi Ahilya University, Indore, MP 452 017, India. drpratihbhasharma@yahoo.com |
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| Abstract: | A number of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives were synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the potent antimicrobial activity. The quantitative structure-activity relationship investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity. |
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